Use of Heterologous Vesiculovirus G Proteins Circumvents the Humoral Anti-envelope Immunity in Lentivector-Based In Vivo Gene Delivery

• Main Authors: Altar M. Munis (Author), Giada Mattiuzzo (Author), Emma M. Bentley (Author), Mary K. Collins (Author), James E. Eyles (Author), Yasuhiro Takeuchi (Author)
• Formato: Livro
• Publicado em: Elsevier, 2019-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Vesicular stomatitis virus Indiana strain glycoprotein (VSVind.G) mediates broad tissue tropism and efficient cellular uptake. Lentiviral vectors (LVs) are particularly promising, as they can efficiently transduce non-dividing cells and facilitate stable genomic transgene integration; therefore, LVs...