Use of Heterologous Vesiculovirus G Proteins Circumvents the Humoral Anti-envelope Immunity in Lentivector-Based In Vivo Gene Delivery

• Hauptverfasser: Altar M. Munis (VerfasserIn), Giada Mattiuzzo (VerfasserIn), Emma M. Bentley (VerfasserIn), Mary K. Collins (VerfasserIn), James E. Eyles (VerfasserIn), Yasuhiro Takeuchi (VerfasserIn)
• Format: Buch
• Veröffentlicht: Elsevier, 2019-09-01T00:00:00Z.
• Schlagworte: article
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Vesicular stomatitis virus Indiana strain glycoprotein (VSVind.G) mediates broad tissue tropism and efficient cellular uptake. Lentiviral vectors (LVs) are particularly promising, as they can efficiently transduce non-dividing cells and facilitate stable genomic transgene integration; therefore, LVs...