Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant potential for fragment periphery evolution via...

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Main Authors: Tatiana Sharonova (Author), Petr Zhmurov (Author), Stanislav Kalinin (Author), Alessio Nocentini (Author), Andrea Angeli (Author), Marta Ferraroni (Author), Mikhail Korsakov (Author), Claudiu T. Supuran (Author), Mikhail Krasavin (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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