Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

• Hoofdauteurs: Tatiana Sharonova (Auteur), Petr Zhmurov (Auteur), Stanislav Kalinin (Auteur), Alessio Nocentini (Auteur), Andrea Angeli (Auteur), Marta Ferraroni (Auteur), Mikhail Korsakov (Auteur), Claudiu T. Supuran (Auteur), Mikhail Krasavin (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant potential for fragment periphery evolution via...