Neutrophil Cathepsin G, but Not Elastase, Induces Aggregation of MCF-7 Mammary Carcinoma Cells by a Protease Activity-Dependent Cell-Oriented Mechanism

• Hoofdauteurs: Satoru Yui (Auteur), Yuuki Osawa (Auteur), Takeo Ichisugi (Auteur), Riyo Morimoto-Kamata (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

We previously found that a neutrophil serine protease, cathepsin G, weakens adherence to culture substrates and induces E-cadherin-dependent aggregation of MCF-7 human breast cancer cells through its protease activity. In this study, we examined whether aggregation is caused by degradation of adhesi...