Neutrophil Cathepsin G, but Not Elastase, Induces Aggregation of MCF-7 Mammary Carcinoma Cells by a Protease Activity-Dependent Cell-Oriented Mechanism

• Main Authors: Satoru Yui (Author), Yuuki Osawa (Author), Takeo Ichisugi (Author), Riyo Morimoto-Kamata (Author)
• Format: Knjiga
• Izdano: Hindawi Limited, 2014-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

We previously found that a neutrophil serine protease, cathepsin G, weakens adherence to culture substrates and induces E-cadherin-dependent aggregation of MCF-7 human breast cancer cells through its protease activity. In this study, we examined whether aggregation is caused by degradation of adhesi...