A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

• Main Authors: Kakeru Sato (Author), Tatsuya Seki (Author), Asuka Mizutani (Author), Yuka Muranaka (Author), Shiho Hirota (Author), Kodai Nishi (Author), Kana Yamazaki (Author), Ryuichi Nishii (Author), Takeo Nakanishi (Author), Ikumi Tamai (Author), Keiichi Kawai (Author), Masato Kobayashi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. This study in...