A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

• मुख्य लेखकों: Kakeru Sato (लेखक), Tatsuya Seki (लेखक), Asuka Mizutani (लेखक), Yuka Muranaka (लेखक), Shiho Hirota (लेखक), Kodai Nishi (लेखक), Kana Yamazaki (लेखक), Ryuichi Nishii (लेखक), Takeo Nakanishi (लेखक), Ikumi Tamai (लेखक), Keiichi Kawai (लेखक), Masato Kobayashi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. This study in...