Germline variation of Ribonuclease H2 genes in ovarian cancer patients

• Автори: Rahel Polaczek (Автор), Peter Schürmann (Автор), Lisa-Marie Speith (Автор), Robert Geffers (Автор), Matthias Dürst (Автор), Peter Hillemanns (Автор), Tjoung-Wo (Автор), Clemens Liebrich (Автор), Thilo Dörk (Автор)
• Формат: Книга
• Опубліковано: BMC, 2020-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Epithelial ovarian carcinoma (EOC) is a genetically heterogeneous disease that is partly driven by molecular defects in mismatch repair (MMR) or homology-directed DNA repair (HDR). Ribonuclease H2 serves to remove mis-incorporated ribonucleotides from DNA which alleviates HDR mechanisms and...