Germline variation of Ribonuclease H2 genes in ovarian cancer patients

• Príomhchruthaitheoirí: Rahel Polaczek (Údar), Peter Schürmann (Údar), Lisa-Marie Speith (Údar), Robert Geffers (Údar), Matthias Dürst (Údar), Peter Hillemanns (Údar), Tjoung-Wo (Údar), Clemens Liebrich (Údar), Thilo Dörk (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: BMC, 2020-12-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Abstract Epithelial ovarian carcinoma (EOC) is a genetically heterogeneous disease that is partly driven by molecular defects in mismatch repair (MMR) or homology-directed DNA repair (HDR). Ribonuclease H2 serves to remove mis-incorporated ribonucleotides from DNA which alleviates HDR mechanisms and...