SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells

• Main Authors: Huasen Tan (Author), Chenshu Xu (Author), Hang Zeng (Author), Ying Wang (Author), Yingmei Li (Author), Xiaomei Fan (Author), Pan Chen (Author), Yiming Jiang (Author), Xiao Chen (Author), Min Huang (Author), Huichang Bi (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pregnane X receptor (PXR) has been well-established as a critical mediator in regulating important drug metabolizing enzymes and transporter proteins, including cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Previous studies identified that PXR served as a molecular target of SUMOylatio...