The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines

• Autors principals: Stefan Landgraeber (Autor), Marcus Jäger (Autor), Joshua J. Jacobs (Autor), Nadim James Hallab (Autor)
• Format: Llibre
• Publicat: Hindawi Limited, 2014-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15-25 years of use, due to slow progressive subtle inflammation at the bone implant interface. This inflammatory disease state is caused by implant debris acting, primarily, on inna...