The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines

• Main Authors: Stefan Landgraeber (Author), Marcus Jäger (Author), Joshua J. Jacobs (Author), Nadim James Hallab (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15-25 years of use, due to slow progressive subtle inflammation at the bone implant interface. This inflammatory disease state is caused by implant debris acting, primarily, on inna...