Folate-conjugated polyspermine for lung cancer-targeted gene therapy

• Glavni autori: Mei Zhang (Autor), You-Kyoung Kim (Autor), Pengfei Cui (Autor), Jialiang Zhang (Autor), Jianbin Qiao (Autor), Yujing He (Autor), Jinyuan Lyu (Autor), Chengqiong Luo (Autor), Lei Xing (Autor), Hulin Jiang (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2016-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Biodegradable polyamines have long been studied as potential recombinant viral gene vectors. Spermine (SPE) is an endogenous tetra-amine with excellent biocompatibility yet poor gene condensation capacity. We have previously synthesized a polyspermine based on SPE and poly(ethylene glycol) (PEG) dia...