Folate-conjugated polyspermine for lung cancer-targeted gene therapy

• Main Authors: Mei Zhang (Author), You-Kyoung Kim (Author), Pengfei Cui (Author), Jialiang Zhang (Author), Jianbin Qiao (Author), Yujing He (Author), Jinyuan Lyu (Author), Chengqiong Luo (Author), Lei Xing (Author), Hulin Jiang (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biodegradable polyamines have long been studied as potential recombinant viral gene vectors. Spermine (SPE) is an endogenous tetra-amine with excellent biocompatibility yet poor gene condensation capacity. We have previously synthesized a polyspermine based on SPE and poly(ethylene glycol) (PEG) dia...