Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

• Main Authors: Dres Damgaard (Author), Mads Emil Bjørn (Author), Peter Østrup Jensen (Author), Claus Henrik Nielsen (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Protein citrullination catalysed by peptidylarginine deiminase (PAD) may play an important pathogenic role in several chronic inflammatory diseases and malignancies. PAD2, PAD4, and citrullinated proteins are found in the synovium of rheumatoid arthritis patients. PAD activity is dependent on calciu...