Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

• Principais autores: Dres Damgaard (Autor), Mads Emil Bjørn (Autor), Peter Østrup Jensen (Autor), Claus Henrik Nielsen (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Protein citrullination catalysed by peptidylarginine deiminase (PAD) may play an important pathogenic role in several chronic inflammatory diseases and malignancies. PAD2, PAD4, and citrullinated proteins are found in the synovium of rheumatoid arthritis patients. PAD activity is dependent on calciu...