Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction

• Главные авторы: Li Luo (Автор), Yonghong Liang (Автор), Yuanyuan Fu (Автор), Zhiyuan Liang (Автор), Jinfen Zheng (Автор), Jie Lan (Автор), Feihai Shen (Автор), Zhiying Huang (Автор)
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• Опубликовано: MDPI AG, 2022-12-01T00:00:00Z.
• Предметы: article
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Toosendanin (TSN) is a triterpenoid from the fruit or bark of <i>Melia toosendan</i> Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application. Autophagy is a degradation and recycling mechanism to maintain cellu...