Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction

• Váldodahkkit: Li Luo (Dahkki), Yonghong Liang (Dahkki), Yuanyuan Fu (Dahkki), Zhiyuan Liang (Dahkki), Jinfen Zheng (Dahkki), Jie Lan (Dahkki), Feihai Shen (Dahkki), Zhiying Huang (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Toosendanin (TSN) is a triterpenoid from the fruit or bark of <i>Melia toosendan</i> Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application. Autophagy is a degradation and recycling mechanism to maintain cellu...