Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia

• Main Authors: Dario Coletti (Author), Paola Aulino (Author), Eva Pigna (Author), Fabio Barteri (Author), Viviana Moresi (Author), Daniela Annibali (Author), Sergio Adamo (Author), Emanuele Berardi (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer...