Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia

• Hauptverfasser: Dario Coletti (Verfasst von), Paola Aulino (Verfasst von), Eva Pigna (Verfasst von), Fabio Barteri (Verfasst von), Viviana Moresi (Verfasst von), Daniela Annibali (Verfasst von), Sergio Adamo (Verfasst von), Emanuele Berardi (Verfasst von)
• Format: Buch
• Veröffentlicht: Hindawi Limited, 2016-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer...