Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia

• Päätekijät: Dario Coletti (Tekijä), Paola Aulino (Tekijä), Eva Pigna (Tekijä), Fabio Barteri (Tekijä), Viviana Moresi (Tekijä), Daniela Annibali (Tekijä), Sergio Adamo (Tekijä), Emanuele Berardi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 2016-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer...