Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia

• Váldodahkkit: Dario Coletti (Dahkki), Paola Aulino (Dahkki), Eva Pigna (Dahkki), Fabio Barteri (Dahkki), Viviana Moresi (Dahkki), Daniela Annibali (Dahkki), Sergio Adamo (Dahkki), Emanuele Berardi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Hindawi Limited, 2016-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer...