Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake

• Main Authors: Fang Li (Author), Rongfeng Hu (Author), Bin Wang (Author), Yun Gui (Author), Gang Cheng (Author), Song Gao (Author), Lei Ye (Author), Jihui Tang (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Huperzine A (Hup-A) is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion (SPIP) technique and a chylomicron flow...