Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway

• Main Authors: Gensheng Zhang (Author), Qiaoling Wang (Author), Qin Zhou (Author), Renjun Wang (Author), Minze Xu (Author), Huiping Wang (Author), Lei Wang (Author), Christopher S. Wilcox (Author), Ruisheng Liu (Author), En Yin Lai (Author)
• Format: Book
• Published: Karger Publishers, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Tempol is a protective antioxidant against ischemic injury in many animal models. The molecular mechanisms are not well understood. Nuclear factor erythroid 2-related factor (Nrf2) is a master transcription factor during oxidative stress, which is enhanced by activation of protein k...