Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R

• Main Authors: Cornelius Hempel (Author), Frank Totzke (Author), Christoph Schächtele (Author), Abdulkarim Najjar (Author), Wolfgang Sippl (Author), Christoph Ritter (Author), Andreas Hilgeroth (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel 4-benzylamino benzo-anellated pyrrolo[2,3-b]pyridines have been synthesized with varied substitution patterns both at the molecular scaffold of the benzo-anellated ring and at the 4-benzylamino residue. With a structural similarity to substituted thieno[2,3-d]pyrimidines as epidermal growth fa...