Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles

• Автори: Misa Minami (Автор), Hiroko Otake (Автор), Yosuke Nakazawa (Автор), Norio Okamoto (Автор), Naoki Yamamoto (Автор), Hiroshi Sasaki (Автор), Noriaki Nagai (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2021-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

We previously designed ophthalmic formulations (nTRA) containing tranilast nanoparticles (Tra-NPs) with high uptake into ocular tissues. In this study, we used in situ gel (ISG) bases comprising combinations of pluronic F127 (F127) and methylcellulose (MC/F127), pluronic F68 (F68/F127), and Carbopol...