Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles

• Päätekijät: Misa Minami (Tekijä), Hiroko Otake (Tekijä), Yosuke Nakazawa (Tekijä), Norio Okamoto (Tekijä), Naoki Yamamoto (Tekijä), Hiroshi Sasaki (Tekijä), Noriaki Nagai (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2021-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

We previously designed ophthalmic formulations (nTRA) containing tranilast nanoparticles (Tra-NPs) with high uptake into ocular tissues. In this study, we used in situ gel (ISG) bases comprising combinations of pluronic F127 (F127) and methylcellulose (MC/F127), pluronic F68 (F68/F127), and Carbopol...