The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins

• Main Authors: Alexander W. Fischer (Author), Kirstin Albers (Author), Lucia M. Krott (Author), Britta Hoffzimmer (Author), Markus Heine (Author), Hartwig Schmale (Author), Ludger Scheja (Author), Philip L.S.M. Gordts (Author), Joerg Heeren (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin resistance is associated with impaired receptor dependent hepatic uptake of triglyceride-rich lipoproteins (TRL), promoting hypertriglyceridemia and atherosclerosis. Next to low-density lipoprotein (LDL) receptor (LDLR) and syndecan-1, the LDLR-related protein 1 (LRP1) stimulated...