Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

• Hauptverfasser: Nadine Holzleitner (Verfasst von), Thomas Günther (Verfasst von), Roswitha Beck (Verfasst von), Constantin Lapa (Verfasst von), Hans-Jürgen Wester (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-11-01T00:00:00Z.
• Schlagworte: article
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In order to enable ¹⁸F- and ¹⁷⁷Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N. In addition, minigastrin analogues with a prolonged as well as <i>γ</i&...