Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

In order to enable <sup>18</sup>F- and <sup>177</sup>Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N. In addition, minigastrin analogues with a prolonged as well as <i>γ</i&...

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Main Authors: Nadine Holzleitner (Author), Thomas Günther (Author), Roswitha Beck (Author), Constantin Lapa (Author), Hans-Jürgen Wester (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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