Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

• Päätekijät: Nadine Holzleitner (Tekijä), Thomas Günther (Tekijä), Roswitha Beck (Tekijä), Constantin Lapa (Tekijä), Hans-Jürgen Wester (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

In order to enable ¹⁸F- and ¹⁷⁷Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N. In addition, minigastrin analogues with a prolonged as well as <i>γ</i&...