A simplified two-marker immunohistochemistry strategy for Lynch syndrome screening in endometrial cancer patients

• Main Authors: Ala Aiob (Author), Yeo Rae Kim (Author), Kidong Kim (Author), Hyojin Kim (Author), Yong Beom Kim (Author), Duck Woo Kim (Author), Jae Hong No (Author), Soo Hyun Seo (Author), Dong Hoon Suh (Author), Kyoung Un Park (Author)
• Format: Book
• Published: Korean Society of Obstetrics and Gynecology, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To examine the efficacy of MSH6 and PMS2 immunohistochemistry (IHC) as a screening method for Lynch syndrome in endometrial cancer patients. Methods Through multidisciplinary discussions, an institutional MSH6 and PMS2 IHC-initiated cascade test (MSH6, PMS2 IHC→microsatellite instability [...