Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Abstract Background NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus. In the present paper, we describe the identification, in vitro cha...

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Main Authors: Yueling Zhong (Author), Hong Xu (Author), Yi Zhong (Author), Xuemiao Zhang (Author), Ting Zeng (Author), Limei Li (Author), Gaojie Xu (Author), Minhui Li (Author), Jin Liu (Author), Tai Yang (Author)
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Publicado em: BMC, 2019-11-01T00:00:00Z.
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