Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Abstract Background NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus. In the present paper, we describe the identification, in vitro cha...

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Main Authors: Yueling Zhong (Author), Hong Xu (Author), Yi Zhong (Author), Xuemiao Zhang (Author), Ting Zeng (Author), Limei Li (Author), Gaojie Xu (Author), Minhui Li (Author), Jin Liu (Author), Tai Yang (Author)
Format: Book
Published: BMC, 2019-11-01T00:00:00Z.
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