Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

• Autori principali: Yueling Zhong (Autore), Hong Xu (Autore), Yi Zhong (Autore), Xuemiao Zhang (Autore), Ting Zeng (Autore), Limei Li (Autore), Gaojie Xu (Autore), Minhui Li (Autore), Jin Liu (Autore), Tai Yang (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2019-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus. In the present paper, we describe the identification, in vitro cha...