HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure

• Main Authors: Runkuan Yang (Author), Xiaoping Zou (Author), Jyrki Tenhunen (Author), Tor Inge Tønnessen (Author)
• Formato: Libro
• Publicado: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes. ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity. ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlyi...