Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells

• Main Authors: Taekyu Ha (Author), Michael DiPrima (Author), Vishal Koparde (Author), Parthav Jailwala (Author), Hidetaka Ohnuki (Author), Jing-Xin Feng (Author), Murali Palangat (Author), Daniel Larson (Author), Giovanna Tosato (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Advances in gene therapy research have resulted in the successful development of new therapies for clinical use. Here, we explored a gene targeting approach to deplete ephrinB2 from colorectal cancer cells using an inducible lentiviral vector. EphrinB2, a transmembrane ephrin ligand, promotes colore...