Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs

• Váldodahkkit: A.R. Fernandes (Dahkki), N.R. Ferreira (Dahkki), J.F. Fangueiro (Dahkki), A.C. Santos (Dahkki), F.J. Veiga (Dahkki), C. Cabral (Dahkki), A.M. Silva (Dahkki), E.B. Souto (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2017-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties. The greatest disadvantage of nanocrystals is their inherent instability, due to the risk of crystal growth. Thus, the selection of an appropr...