Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs

• Main Authors: A.R. Fernandes (Author), N.R. Ferreira (Author), J.F. Fangueiro (Author), A.C. Santos (Author), F.J. Veiga (Author), C. Cabral (Author), A.M. Silva (Author), E.B. Souto (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties. The greatest disadvantage of nanocrystals is their inherent instability, due to the risk of crystal growth. Thus, the selection of an appropr...