Functional assays to determine the significance of two common <it>XPC </it>3'UTR variants found in bladder cancer patients

• Main Authors: Bishop D (Author), Hall Janet (Author), Bentley Johanne (Author), Vaslin Laurence (Author), Elliott Faye (Author), Scott Gina B (Author), Qiao Boling (Author), Knowles Margaret A (Author), Kiltie Anne E (Author)
• Format: Bog
• Udgivet: BMC, 2011-06-01T00:00:00Z.
• Fag: article
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<p>Abstract</p> <p>Background</p> <p><it>XPC </it>is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for the variant allele of <it>XPC </it>c.1496C > T (p.Ala499Val...