Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice

• Main Authors: Mikala M. Zelows (Author), Corissa Cady (Author), Nikitha Dharanipragada (Author), Anna E. Mead (Author), Zachary A. Kipp (Author), Evelyn A. Bates (Author), Venkateshwari Varadharajan (Author), Rakhee Banerjee (Author), Se-Hyung Park (Author), Nathan R. Shelman (Author), Harrison A. Clarke (Author), Tara R. Hawkinson (Author), Terrymar Medina (Author), Ramon C. Sun (Author), Todd A. Lydic (Author), Terry D. Hinds, Jr (Author), J. Mark Brown (Author), Samir Softic (Author), Gregory A. Graf (Author), Robert N. Helsley (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and aims: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic lipid metabolism. Approach and results: Male and f...