The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult

• Main Authors: Hannah Ceuleers (Author), Nikita Hanning (Author), Michelle De bruyn (Author), Joris G De Man (Author), Heiko U De Schepper (Author), Qian Li (Author), Liansheng Liu (Author), Steven Abrams (Author), Annemieke Smet (Author), Jurgen Joossens (Author), Koen Augustyns (Author), Ingrid De Meester (Author), Pankaj J Pasricha (Author), Benedicte Y De Winter (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic administration of a serine protease inhibitor. The...