Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion

• Main Authors: Zhouji Chen (Author), Shiyu Wang (Author), Anita Pottekat (Author), Alec Duffey (Author), Insook Jang (Author), Benny H. Chang (Author), Jaehyung Cho (Author), Brian N. Finck (Author), Nicholas O. Davidson (Author), Randal J. Kaufman (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The assembly and secretion of hepatic very low-density lipoprotein (VLDL) plays pivotal roles in hepatic and plasma lipid homeostasis. Protein disulfide isomerase A1 (PDIA1/P4HB) is a molecular chaperone whose functions are essential for protein folding in the endoplasmic reticulum. Here...