Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion

• मुख्य लेखकों: Zhouji Chen (लेखक), Shiyu Wang (लेखक), Anita Pottekat (लेखक), Alec Duffey (लेखक), Insook Jang (लेखक), Benny H. Chang (लेखक), Jaehyung Cho (लेखक), Brian N. Finck (लेखक), Nicholas O. Davidson (लेखक), Randal J. Kaufman (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: The assembly and secretion of hepatic very low-density lipoprotein (VLDL) plays pivotal roles in hepatic and plasma lipid homeostasis. Protein disulfide isomerase A1 (PDIA1/P4HB) is a molecular chaperone whose functions are essential for protein folding in the endoplasmic reticulum. Here...