Exploring the Leukemogenic Potential of GATA-1_S, the Shorter Isoform of GATA-1: Novel Insights into Mechanisms Hampering Respiratory Chain Complex II Activity and Limiting Oxidative Phosphorylation Efficiency

• Main Authors: Silvia Trombetti (Author), Raffaele Sessa (Author), Rosa Catapano (Author), Laura Rinaldi (Author), Alessandra Lo Bianco (Author), Antonio Feliciello (Author), Paola Izzo (Author), Michela Grosso (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GATA-1 is a key regulator of hematopoiesis. A balanced ratio of its two isoforms, GATA-1_FL and GATA-1_S, contributes to normal hematopoiesis, whereas aberrant expression of GATA-1_S alters the differentiation/proliferation potential...