Trans-cyclooctene-a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs

• Main Authors: Karuna Adhikari (Author), Maarten Vanermen (Author), Gustavo Da Silva (Author), Tim Van den Wyngaert (Author), Koen Augustyns (Author), Filipe Elvas (Author)
• 格式: 圖書
• 出版: SpringerOpen, 2024-06-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Background Trans-cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand Diels-Alder reactions. Since their discovery as bioorthogonal reaction partners, novel TCO derivatives have been developed to improve their reactiv...