Trans-cyclooctene-a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs

• Κύριοι συγγραφείς: Karuna Adhikari (Συγγραφέας), Maarten Vanermen (Συγγραφέας), Gustavo Da Silva (Συγγραφέας), Tim Van den Wyngaert (Συγγραφέας), Koen Augustyns (Συγγραφέας), Filipe Elvas (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: SpringerOpen, 2024-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Background Trans-cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand Diels-Alder reactions. Since their discovery as bioorthogonal reaction partners, novel TCO derivatives have been developed to improve their reactiv...