Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

• Autors principals: Shu-Tao Xie (Autor), Wen-Chu Fan (Autor), Xian-Sen Zhao (Autor), Xiao-Yang Ma (Autor), Ze-Lin Li (Autor), Yan-Ran Zhao (Autor), Fa Yang (Autor), Ying Shi (Autor), Hui Rong (Autor), Zhi-San Cui (Autor), Jun-Yi Chen (Autor), Hong-Zhao Li (Autor), Chao Yan (Autor), Qipeng Zhang (Autor), Jian-Jun Wang (Autor), Xiao-Yang Zhang (Autor), Xiao-Ping Gu (Autor), Zheng-Liang Ma (Autor), Jing-Ning Zhu (Autor)
• Format: Llibre
• Publicat: Elsevier, 2023-05-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking. Notably, cerebellar microglial activation appears to be a common feature in different types of ataxic patients and rode...