Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

• Main Authors: Shuang Lei (Author), Jian Li (Author), Jingjun Yu (Author), Fulong Li (Author), Yaping Pan (Author), Xu Chen (Author), Chunliang Ma (Author), Weidong Zhao (Author), Xiaolin Tang (Author)
• Format: Book
• Published: Nature Publishing Group, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer's disease (AD). The blood-brain barrier (BBB) is essential for keeping...