The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
IntroductionPregnancy results in significant changes in drug pharmacokinetics (PK). While previous studies have elucidated the impact of pregnancy-related hormones (PRH) on mRNA or protein expression and activity of major hepatic metabolizing enzymes, their effect on hepatic drug transporters remain...
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Frontiers Media S.A.,
2024-08-01T00:00:00Z.
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