The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

• Huvudskapare: Jhohann Richard de Lima Benzi (Författare, medförfattare), Yik Pui Tsang (Författare, medförfattare), Jashvant D. Unadkat (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

IntroductionPregnancy results in significant changes in drug pharmacokinetics (PK). While previous studies have elucidated the impact of pregnancy-related hormones (PRH) on mRNA or protein expression and activity of major hepatic metabolizing enzymes, their effect on hepatic drug transporters remain...