Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers - antiherpes activity and penetration behavior across the human vaginal epithelium

• Main Authors: Emilia Szymańska (Author), Małgorzata Krzyżowska (Author), Krzysztof Cal (Author), Barbara Mikolaszek (Author), Jakub Tomaszewski (Author), Sławomir Wołczyński (Author), Katarzyna Winnicka (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit carriers with zidovudine (ZVD) as a model antiretrov...