Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents

• Glavni autori: Jaeok Lee (Autor), Jiyeon Kang (Autor), Na-Yun Kwon (Autor), Aneesh Sivaraman (Autor), Ravi Naik (Autor), So-Young Jin (Autor), A. Reum Oh (Autor), Jae-Ho Shin (Autor), Younghwa Na (Autor), Kyeong Lee (Autor), Hwa-Jeong Lee (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed in clinical trials due to low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have been examined to surmount this limitation. We examined breast can...