Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents

• Main Authors: Jaeok Lee (Author), Jiyeon Kang (Author), Na-Yun Kwon (Author), Aneesh Sivaraman (Author), Ravi Naik (Author), So-Young Jin (Author), A. Reum Oh (Author), Jae-Ho Shin (Author), Younghwa Na (Author), Kyeong Lee (Author), Hwa-Jeong Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed in clinical trials due to low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have been examined to surmount this limitation. We examined breast can...