Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

• Main Authors: Noëmi Johanna Roos (Author), Diell Aliu (Author), Jamal Bouitbir (Author), Stephan Krähenbühl (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumulation of reactive oxygen species. The effect of lap...