Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumulation of reactive oxygen species. The effect of lap...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2020-06-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |